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31,623,935 | The Emergency Department Trigger Tool: A Novel Approach to Screening for Quality and Safety Events. | Annals of emergency medicine | Ann Emerg Med | 76 | 2 | 10.1016/j.annemergmed.2019.07.032 | eng | 2,020 | 8 | null | 2,019 | 10 | 14 | [STUDY OBJECTIVE] Trigger tools improve surveillance for harm by focusing reviews on records with "triggers" whose presence increases the likelihood of an adverse event. We refine and automate a previously developed emergency department (ED) trigger tool and present record selection strategies to further optimize yield... | null | 1.241 | 178 | Emergency Medicine | Medicine | 2,020 |
31,623,934 | Google Versus PubMed: Comparison of Google and PubMed's Search Tools for Answering Clinical Questions in the Emergency Department. | Annals of emergency medicine | Ann Emerg Med | 75 | 3 | 10.1016/j.annemergmed.2019.07.003 | eng | 2,020 | 3 | null | 2,019 | 10 | 14 | [STUDY OBJECTIVE] We assess which search tool returns the highest-quality, most relevant citations for standardized clinical questions arising at the point of care in the emergency department (ED). [METHODS] Search terms related to 3 clinical questions commonly encountered in the ED were entered into 5 search tools. Th... | null | 1.241 | 178 | Emergency Medicine | Medicine | 2,020 |
31,623,931 | Birth Mode after Primary Cesarean among Hispanic and non-Hispanic Women at One U.S. Institution. | Women's health issues : official publication of the Jacobs Institute of Women's Health | Womens Health Issues | 30 | 1 | 10.1016/j.whi.2019.09.001 | eng | 2,020 | null | null | 2,019 | 10 | 14 | [BACKGROUND] Despite a lower percentage of primary cesareans than non-Hispanic White and Black women, Hispanic women in the United States had the highest rate of repeat cesarean deliveries (RCD) in 2016; it is unclear if reasons for differences are due to known risk factors. Our study examined the association between e... | null | 1.325 | 75 | Health; Maternity and Midwifery; Obstetrics and Gynecology; Public Health, Environmental and Occupational Health | Medicine; Nursing; Social Sciences | 2,020 |
31,623,930 | Clinical findings of gadolinium-enhanced cardiac magnetic resonance in Fabry patients. | Journal of cardiology | J Cardiol | 75 | 1 | 10.1016/j.jjcc.2019.09.002 | eng | 2,020 | 1 | null | 2,019 | 10 | 15 | [BACKGROUND] Fabry disease is one of the causes of left ventricular hypertrophy (LVH) and can be treated with enzyme replacement therapy or pharmacological chaperone therapy. Late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) can identify myocardial fibrosis and be used for the stratification in LVH.... | Fabry disease; Left ventricular hypertrophy; Magnetic resonance imaging | 1.058 | 66 | Cardiology and Cardiovascular Medicine | Medicine | 2,020 |
31,623,917 | Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea. | Vaccine | Vaccine | 37 | 48 | 10.1016/j.vaccine.2019.09.094 | eng | 2,019 | 11 | 15 | 2,019 | 10 | 14 | [BACKGROUND] Alongside the clinical aspects of the immunogenicity and safety trial of an Ebola vaccine deployed among front-line workers, a qualitative study was conducted to describe motivations behind individuals' decisions to participate - or not to participate - in the study. [METHODS] In July and August 2015, focu... | Ebola virus disease; Guinea; Healthcare workers; Qualitative; Research design; rVSV vaccine | 1.683 | 222 | Immunology and Microbiology; Infectious Diseases; Molecular Medicine; Public Health, Environmental and Occupational Health; Veterinary | Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary | 2,019 |
31,623,908 | Overexpression of Cyclophilin A in Human Periapical Lesions. | Journal of endodontics | J Endod | 45 | 12 | 10.1016/j.joen.2019.09.006 | eng | 2,019 | 12 | null | 2,019 | 10 | 14 | [INTRODUCTION] Cyclophilin A (CypA) is a cytosolic protein involved in multiple biological functions, such as inflammation, tissue remodeling, tumorigenesis, and vascular diseases. Human periapical lesions are induced by bacterial infections. However, the expression of CypA in human periapical lesions remains unclear. ... | Angiogenesis; CD147; CD34; cyclophilin A; matrix metalloproteinase 9; periapical lesions | 1.689 | 189 | Dentistry | Dentistry | 2,019 |
31,623,902 | Outcomes of elderly patients with nondisplaced or minimally displaced femoral neck fractures treated with internal fixation: A systematic review and meta-analysis. | Injury | Injury | 50 | 12 | 10.1016/j.injury.2019.09.039 | eng | 2,019 | 12 | null | 2,019 | 10 | 1 | [BACKGROUND] Internal fixation remains the treatment of choice for non-displaced femoral neck fractures in elderly patients. Improved outcomes with arthroplasty following displaced femoral neck fractures may indicate that outcomes of non-displaced patterns should be reexamined. The aim of our study was to conduct a sys... | Elderly; Femoral neck fracture; Fracture; Internal fixation; Minimally displaced; Nondisplaced; Osteoporosis | 0.904 | 151 | Emergency Medicine; Orthopedics and Sports Medicine; Surgery | Medicine | 2,019 |
31,623,901 | Acute kidney injury following hip fracture. | Injury | Injury | 50 | 12 | 10.1016/j.injury.2019.10.008 | eng | 2,019 | 12 | null | 2,019 | 10 | 4 | [BACKGROUND] Hip fracture causes disability and excess mortality in the aging population. Acute kidney injury (AKI), is known to diminish survival of critically ill and trauma patients. AKI is also a common perioperative complication among surgical patients. We examined the effect of AKI on the survival of hip fracture... | AKI; Acute kidney injury; Hip fracture; Incidence; Mortality | 0.904 | 151 | Emergency Medicine; Orthopedics and Sports Medicine; Surgery | Medicine | 2,019 |
31,623,899 | Two new models for the estimation of foetal weight more than a week before delivery: An MRI study. | European journal of radiology | Eur J Radiol | 121 | null | 10.1016/j.ejrad.2019.06.026 | eng | 2,019 | 12 | null | 2,019 | 6 | 28 | [PURPOSE] To develop and evaluate new formulas to determine the magnetic resonance imaging (MRI)-based estimated foetal weight (EFW) more than a week before delivery. [METHODS] The study included 153 women with singleton pregnancies who gave birth to live, normal neonates within 15-21 days of the MRI examination for wh... | Foetal weight estimation; Magnetic resonance imaging; Term | 1.082 | 139 | Medicine; Radiology, Nuclear Medicine and Imaging | Medicine | 2,019 |
31,623,897 | Effects of preoperative radiotherapy or chemoradiotherapy on postoperative pathological outcome of cervical cancer--from the large database of 46,313 cases of cervical cancer in China. | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | Eur J Surg Oncol | 46 | 1 | 10.1016/j.ejso.2019.09.188 | eng | 2,020 | 1 | null | 2,019 | 10 | 7 | [OBJECTIVE] To investigate the effect of preoperative radiotherapy or chemoradiotherapy combined with radical surgery on pathological outcomes in cervical cancer patients. [METHODS] Based on a large Chinese cervical cancer database of clinical diagnosis and treatment (C4 Project), the postoperative pathological outcome... | Cervical cancer; Pathology; Radiotherapy; Radiotherapy and chemotherapy | 1.395 | 123 | Medicine; Surgery; Oncology | Medicine | 2,020 |
31,623,881 | Exploring the relationship between burnout and grit during general surgery residency: A longitudinal, single-institution analysis. | American journal of surgery | Am J Surg | 219 | 2 | 10.1016/j.amjsurg.2019.09.041 | eng | 2,020 | 2 | null | 2,019 | 10 | 8 | [BACKGROUND] How burnout changes during general surgery residency remains unknown. [METHODS] From 2015 to 2018, general surgery residents completed the Maslach Burnout Inventory and Grit Scale. Statistical analyses were adjusted for repeated measures and compared to the incoming intern level. [RESULTS] Fifty-five resid... | Burnout; Grit; Surgical education; Surgical residency; Wellbeing | 0.957 | 173 | Medicine; Surgery | Medicine | 2,020 |
31,623,880 | The impact of medical student interest in surgery on clerkship performance and career choice. | American journal of surgery | Am J Surg | 219 | 2 | 10.1016/j.amjsurg.2019.09.040 | eng | 2,020 | 2 | null | 2,019 | 10 | 9 | [BACKGROUND] Interest in surgery has declined for two decades. This study aimed to evaluate the impact of one's interest in surgery on career choice. [METHODS] Students who completed the surgical clerkship (2016-2017) were invited to complete surveys assessing rotation experience, learning style, burnout, and grit. Stu... | Burnout; Grit; Learning styles; Medical students; Surgical education | 0.957 | 173 | Medicine; Surgery | Medicine | 2,020 |
31,623,879 | Changes in splenic capsule with aging; beliefs and reality. | American journal of surgery | Am J Surg | 220 | 1 | 10.1016/j.amjsurg.2019.09.035 | eng | 2,020 | 7 | null | 2,019 | 9 | 28 | [BACKGROUND] Research describing the splenic capsule and its effect on non-operative management of splenic injuries is limited. The aim of this study is to identify the current beliefs about the splenic capsule thickness and investigate changes in the splenic capsule with age. [METHODS] Trauma Medical Directors were su... | Non-operative; Pediatrics; Spleen; Splenic capsule thickness; Trauma | 0.957 | 173 | Medicine; Surgery | Medicine | 2,020 |
31,623,873 | The 2013 ACC/AHA risk score and subclinical cardiac remodeling and dysfunction: Complementary in cardiovascular disease prediction. | International journal of cardiology | Int J Cardiol | 297 | null | 10.1016/j.ijcard.2019.09.061 | eng | 2,019 | 12 | 15 | 2,019 | 10 | 9 | [BACKGROUND] Echocardiography might enhance cardiovascular (CV) risk stratification beyond tools grading the risk for atherosclerotic CV diseases (ASCVD). We therefore studied the complementarity between the ASCVD risk score recommended by American cardiology societies and echocardiographic profiling in predicting adve... | Atherosclerotic cardiovascular disease; Cardiovascular risk score; Echocardiography; Risk stratification | 1.082 | 155 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,869 | An Age- and Stage-Appropriate Patient-Reported Outcome Measure of Vision-Related Quality of Life of Children and Young People with Visual Impairment. | Ophthalmology | Ophthalmology | 127 | 2 | 10.1016/j.ophtha.2019.08.033 | eng | 2,020 | 2 | null | 2,019 | 9 | 10 | [PURPOSE] Developmentally sensitive measures of vision-related quality of life (VQoL) are needed to capture age-specific concerns about the impact of living with visual impairment (VI) in children and young people. Our objective was to use our validated VQoL instrument for children and young people 10 to 15 years of ag... | null | 5.028 | 297 | Ophthalmology | Medicine | 2,020 |
31,623,863 | GC-Net: Global context network for medical image segmentation. | Computer methods and programs in biomedicine | Comput Methods Programs Biomed | 190 | null | 10.1016/j.cmpb.2019.105121 | eng | 2,020 | 7 | null | 2,019 | 10 | 4 | [BACKGROUND AND OBJECTIVE] Medical image segmentation plays an important role in many clinical applications such as disease diagnosis, surgery planning, and computer-assisted therapy. However, it is a very challenging task due to variant images qualities, complex shapes of objects, and the existence of outliers. Recent... | Convolutional neural network; Global context; Medical image segmentation; Spatial and excitation pyramid pooling | 0.924 | 150 | Computer Science Applications; Software; Health Informatics | Computer Science; Medicine | 2,020 |
31,623,857 | Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study. | Gynecologic oncology | Gynecol Oncol | 155 | 3 | 10.1016/j.ygyno.2019.09.024 | eng | 2,019 | 12 | null | 2,019 | 10 | 15 | [OBJECTIVE] We sought to determine safety and efficacy of the AKT inhibitor, GSK2141795, combined with the MEK inhibitor, trametinib, in endometrial cancer. [METHODS] Patients with measurable recurrent endometrial cancer were eligible. One to two prior cytotoxic regimens were allowed; prior use of a MEK or PI3K pathway... | AKT inhibition; Endometrial cancer; KRAS mutation; MEK inhibition; NRG oncology; PI3K | 2.463 | 192 | Obstetrics and Gynecology; Oncology | Medicine | 2,019 |
31,623,856 | Outcomes from the Centers for Disease Control and Prevention 2018 Breastfeeding Report Card: Public Policy Implications. | The Journal of pediatrics | J Pediatr | 218 | null | 10.1016/j.jpeds.2019.08.059 | eng | 2,020 | 3 | null | 2,019 | 10 | 14 | [OBJECTIVES] To compare the impact of Baby-Friendly designation vs rates of in-hospital breastfeeding initiation on breastfeeding outcomes at 3, 6, and 12 months postdischarge. [STUDY DESIGN] Breastfeeding outcome data from the 2018 Centers for Disease Control (CDC) Breastfeeding Report Card were used as a basis for de... | Baby-Friendly; breastfeeding | 1.227 | 246 | Pediatrics, Perinatology and Child Health | Medicine | 2,020 |
31,623,853 | Differences in long-term quality of life between hemithyroidectomy and total thyroidectomy in patients treated for low-risk differentiated thyroid carcinoma. | Surgery | Surgery | 167 | 1 | 10.1016/j.surg.2019.04.060 | eng | 2,020 | 1 | null | 2,019 | 10 | 15 | [BACKGROUND] The long-term health-related quality-of-life implications of treating low-risk differentiated thyroid cancer with total thyroidectomy or hemithyroidectomy is important to patients but remains poorly understood. [METHODS] Using a cross-sectional mailed survey, we compared long-term health-related quality-of... | null | null | null | null | null | null |
31,623,849 | Value of an abbreviated protocol of breast magnetic resonance imaging for screening high-risk patients. | Radiologia | Radiologia (Engl Ed) | 62 | 3 | 10.1016/j.rx.2019.08.001 | eng | 2,020 | null | null | 2,019 | 10 | 14 | [OBJECTIVE] Value the utility of breast MRI abbreviated protocols for the screening of breast cancer in high-risk patients compared to the full protocol. [METHODS] We performed a retrospective review of 157 breast MRI of 82 high-risk patients practiced in our hospital between January 2011 and January 2017. Clinical, ra... | Abbreviated protocol; Alto riesgo; Breast cancer; Breast magnetic resonance; Cancer screening; Cribado; High-risk; Protocolo abreviado; RM mamaria | 0.22 | 22 | Radiology, Nuclear Medicine and Imaging | Medicine | 2,020 |
31,623,843 | Consumption of Ultra-Processed Foods and Mortality: A National Prospective Cohort in Spain. | Mayo Clinic proceedings | Mayo Clin Proc | 94 | 11 | 10.1016/j.mayocp.2019.03.035 | eng | 2,019 | 11 | null | 2,019 | 10 | 14 | [OBJECTIVE] To assess the prospective association between ultra-processed food consumption and all-cause mortality and to examine the effect of theoretical iso-caloric non-processed foods substitution. [PATIENTS AND METHODS] A population-based cohort of 11,898 individuals (mean age 46.9 years, and 50.5% women) were sel... | null | 2.18 | 221 | Medicine | Medicine | 2,019 |
31,623,842 | Perioperative adverse events attributed to α2-adrenoceptor agonists in patients not at risk of cardiovascular events: systematic review and meta-analysis. | British journal of anaesthesia | Br J Anaesth | 123 | 6 | 10.1016/j.bja.2019.07.029 | eng | 2,019 | 12 | null | 2,019 | 10 | 14 | [BACKGROUND] Several systematic reviews have reported the benefits of perioperative α2-adrenoceptor agonist use for various conditions, but safety evidence is poorly documented. [METHODS] We performed a systematic review focusing on adverse events. We searched the MEDLINE, Embase, LILACS, Cochrane, and Clinical Trials ... | adverse effect; clonidine; dexmedetomidine; meta-analysis; systematic review | 2.393 | 222 | Anesthesiology and Pain Medicine | Medicine | 2,019 |
31,623,841 | Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. | British journal of anaesthesia | Br J Anaesth | 123 | 6 | 10.1016/j.bja.2019.08.026 | eng | 2,019 | 12 | null | 2,019 | 10 | 14 | [BACKGROUND] Spinal cord injury induces inflammatory responses that include the release of cytokines and the recruitment and activation of macrophages and microglia. Neuroinflammation at the lesion site contributes to secondary tissue injury and permanent locomotor dysfunction. Dexmedetomidine (DEX), a highly selective... | dexmedetomidine; macrophage polarisation; microglia; neuroinflammation; spinal cord injury | 2.393 | 222 | Anesthesiology and Pain Medicine | Medicine | 2,019 |
31,623,840 | Results of a phase 1 multicentre investigation of dexmedetomidine bolus and infusion in corrective infant cardiac surgery. | British journal of anaesthesia | Br J Anaesth | 123 | 6 | 10.1016/j.bja.2019.06.026 | eng | 2,019 | 12 | null | 2,019 | 10 | 14 | [BACKGROUND] Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing f... | anaesthesia; congenital heart surgery; dexmedetomidine; pharmacokinetics; tetralogy of Fallot; transposition of the great arteries; ventricular septal defect | 2.393 | 222 | Anesthesiology and Pain Medicine | Medicine | 2,019 |
31,623,837 | Effect of polyvinylphosphonic acid on resin-dentin bonds and the cytotoxicity of mouse dental papilla cell-23. | The Journal of prosthetic dentistry | J Prosthet Dent | 122 | 5 | 10.1016/j.prosdent.2019.08.011 | eng | 2,019 | 11 | null | 2,019 | 10 | 15 | [STATEMENT OF PROBLEM] Polyvinylphosphonic acid (PVPA) could be used as a biomimetic remineralization analog and a matrix metalloproteinases (MMPs) inhibitor. However, studies are lacking regarding the performance of PVPA in dental bonding systems for maintaining the durability of the resin-dentin bond. [PURPOSE] The p... | null | 1.151 | 160 | Medicine; Oral Surgery | Dentistry; Medicine | 2,019 |
31,623,836 | Influence of various airborne-particle abrasion conditions on bonding between zirconia ceramics and an indirect composite resin material. | The Journal of prosthetic dentistry | J Prosthet Dent | 122 | 5 | 10.1016/j.prosdent.2019.08.016 | eng | 2,019 | 11 | null | 2,019 | 10 | 15 | [STATEMENT OF PROBLEM] Indirect composite resins (ICRs) have been suggested as veneering materials for implant-supported zirconia-based fixed dental prostheses; however, obtaining a durable bond between the zirconia ceramic and the ICR is a challenge. [PURPOSE] The purpose of this in vitro study was to evaluate the inf... | null | 1.151 | 160 | Medicine; Oral Surgery | Dentistry; Medicine | 2,019 |
31,623,833 | Sodium Tanshinone IIA sulfonate improves post-ischemic angiogenesis in hyperglycemia. | Biochemical and biophysical research communications | Biochem Biophys Res Commun | 520 | 3 | 10.1016/j.bbrc.2019.09.106 | eng | 2,019 | 12 | 10 | 2,019 | 10 | 14 | [BACKGROUND] Diabetes is a strong risk factor of peripheral arterial disease (PAD), and also leads to impaired perfusion recovery in the ischemic limb, which eventually results in poor outcomes in PAD patients. Sodium Tanshinone IIA Sulfonate (STS), a monomer from herbs, has been shown to improve the outcomes in a vari... | Angiogenesis; Diabetes; Peripheral Arterial Disease; Reactive oxygen species; Sodium Tanshinone IIA sulfonate | 0.966 | 298 | Biophysics; Biochemistry; Cell Biology; Molecular Biology | Biochemistry, Genetics and Molecular Biology | 2,019 |
31,623,829 | Inhibition of core fucosylation limits progression of diabetic kidney disease. | Biochemical and biophysical research communications | Biochem Biophys Res Commun | 520 | 3 | 10.1016/j.bbrc.2019.10.037 | eng | 2,019 | 12 | 10 | 2,019 | 10 | 14 | [BACKGROUND] FUT8-mediated core fucosylation, which transfers a fucose residue from GDP-fucose to core-GlcNAc of the N-linked type glycoproteins, is crucial for signaling receptors function. Core fucosylation is involved in various biological processes such as cell proliferation, apoptosis, differentiation and immune r... | Core fucosylation; Diabetic kidney disease; FUT8; Podocyte | 0.966 | 298 | Biophysics; Biochemistry; Cell Biology; Molecular Biology | Biochemistry, Genetics and Molecular Biology | 2,019 |
31,623,825 | Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus. | Biological psychiatry | Biol Psychiatry | 87 | 6 | 10.1016/j.biopsych.2019.08.009 | eng | 2,020 | 3 | 15 | 2,019 | 8 | 23 | [BACKGROUND] Activation of serotonin (5-HT) type 4 receptors (5-HT4Rs) has been shown to have anxiolytic effects in a variety of animal models. Characterizing the circuits responsible for these effects should offer insights into new approaches to treat anxiety. [METHODS] We evaluated whether acute 5-HT4R activation in ... | 5-HT(4) Receptor agonist; Anxiety; Benzodiazepine; Dorsal raphe nucleus; Fast onset; Optogenetic; Prefrontal cortex | 5.335 | 367 | Biological Psychiatry | Neuroscience | 2,020 |
31,623,818 | Racial Disparities in the Clinical Presentation and Prognosis of Patients with Mycosis Fungoides. | Journal of the National Medical Association | J Natl Med Assoc | 111 | 6 | 10.1016/j.jnma.2019.08.006 | eng | 2,019 | 12 | null | 2,019 | 10 | 15 | [OBJECTIVE] Racial and gender disparities in mycosis fungoides (MF) are understudied. The objective of this study was to test the hypothesis that worse prognosis in blacks with MF is mediated by higher disease stage at diagnosis and by earlier disease onset in black females. [METHODS] We conducted retrospective chart r... | Disparities; Gender; Mycosis fungoides; Race | 0.355 | 87 | Medicine | Medicine | 2,019 |
31,623,811 | Propensity-score adjusted comparison of pathologic nodal upstaging by robotic, video-assisted thoracoscopic, and open lobectomy for non-small cell lung cancer. | The Journal of thoracic and cardiovascular surgery | J Thorac Cardiovasc Surg | 158 | 5 | 10.1016/j.jtcvs.2019.06.113 | eng | 2,019 | 11 | null | 2,019 | 8 | 28 | [OBJECTIVE] To assess the effectiveness of intraoperative lymph node (LN) staging by comparing upstaging between robotic-assisted surgery, video-assisted thoracoscopic surgery (VATS), and open thoracotomy approach for lobectomy for non-small cell lung cancer. [METHODS] We retrospectively analyzed 1053 patients with cli... | VATS; lobectomy lymph node; robotic; upstaging | 1.608 | 225 | Cardiology and Cardiovascular Medicine; Pulmonary and Respiratory Medicine; Surgery | Medicine | 2,019 |
31,623,766 | Individualizing Revascularization Strategy for Diabetic Patients With Multivessel Coronary Disease. | Journal of the American College of Cardiology | J Am Coll Cardiol | 74 | 16 | 10.1016/j.jacc.2019.07.083 | eng | 2,019 | 10 | 22 | null | null | null | [BACKGROUND] In patients with diabetes and multivessel coronary artery disease (CAD), the FREEDOM (Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease) trial demonstrated that, on average, coronary artery bypass grafting (CABG) was superior to percutaneous c... | coronary artery bypass graft; coronary artery disease; diabetes; multivessel disease; percutaneous coronary intervention; personalized risk estimate; shared decision making | 9.989 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,764 | Guiding Therapy by Coronary CT Angiography Improves Outcomes in Patients With Stable Chest Pain. | Journal of the American College of Cardiology | J Am Coll Cardiol | 74 | 16 | 10.1016/j.jacc.2019.07.085 | eng | 2,019 | 10 | 22 | null | null | null | [BACKGROUND] Within the SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) trial of patients with stable chest pain, the use of coronary computed tomography angiography (CTA) reduced the rate of death from coronary heart disease or nonfatal myocardial infarction (primary endpoint). [OBJECTIVES] This study sou... | angina pectoris; computed tomography; coronary heart disease | 9.989 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,762 | Implanted Monitor Alerting to Reduce Treatment Delay in Patients With Acute Coronary Syndrome Events. | Journal of the American College of Cardiology | J Am Coll Cardiol | 74 | 16 | 10.1016/j.jacc.2019.07.084 | eng | 2,019 | 10 | 22 | null | null | null | [BACKGROUND] Increased pre-hospital delay during acute coronary syndrome (ACS) events contributes to worse outcome. [OBJECTIVES] The purpose of this study was to assess the effectiveness of an implanted cardiac monitor with real-time alarms for abnormal ST-segment shifts to reduce pre-hospital delay during ACS events. ... | implantable cardiac monitor; ischemia monitoring; pre-hospital delay; silent myocardial infarction; supply-side ischemia; symptom-to-door time | 9.989 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,760 | Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome. | Journal of the American College of Cardiology | J Am Coll Cardiol | 74 | 16 | 10.1016/j.jacc.2019.07.082 | eng | 2,019 | 10 | 22 | null | null | null | [BACKGROUND] Major disparities between women and men in the diagnosis, management, and outcomes of acute coronary syndrome are well recognized. [OBJECTIVES] The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial... | acute coronary syndrome; high-sensitivity cardiac troponin; myocardial infarction; sex-specific threshold | 9.989 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,758 | Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Multivessel PCI. | Journal of the American College of Cardiology | J Am Coll Cardiol | 74 | 16 | 10.1016/j.jacc.2019.08.997 | eng | 2,019 | 10 | 22 | null | null | null | [BACKGROUND] Data on optimal antiplatelet treatment regimens in patients who undergo multivessel percutaneous coronary intervention (PCI) are sparse. [OBJECTIVES] This post hoc study investigated the impact of an experimental strategy (1-month dual antiplatelet therapy [DAPT] followed by 23-month ticagrelor monotherapy... | drug-eluting stent; dual antiplatelet therapy; multivessel percutaneous coronary intervention; ticagrelor monotherapy | 9.989 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,019 |
31,623,703 | Analysis of diagnostic data for sexually transmissible infections in South Australian Aboriginal Community Controlled Health Services (2008-16). | Sexual health | Sex Health | 16 | 6 | 10.1071/SH18189 | eng | 2,019 | 11 | null | null | null | null | [UNLABELLED] Australian Aboriginal communities experience a high burden of sexually transmissible infections (STIs). Since 2009, a comprehensive sexual health program has been implemented at nine Aboriginal Community Controlled Health Services in South Australia. This study assessed trends in STI testing and positivity... | null | null | null | null | null | null |
31,623,690 | Circulating adult stem and progenitor cell numbers-can results be trusted? | Stem cell research & therapy | Stem Cell Res Ther | 10 | 1 | 10.1186/s13287-019-1403-x | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Within the last years, the interest in physical exercise as non-invasive stimulus influencing circulating hematopoietic stem and progenitor cell (CPC) concentrations has constantly grown. Cell estimates are often derived by determining the subgroup of CPC as percent lymphocytes (LYM) or mononuclear cells (... | CD34+/CD45dim; Density gradient centrifugation; Hematopoietic progenitor cell; Lymphocyte-to-monocyte ratio; Red blood cell lysis | null | null | null | null | null |
31,623,686 | Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences. | Epigenetics & chromatin | Epigenetics Chromatin | 12 | 1 | 10.1186/s13072-019-0309-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retain differences in allelic methylation status throughout fertilization and subsequent somatic cell d... | Cdkn1c; DNA methylation; Epigenetics; Genomic imprinting; H19; Ndn; Peg12; Secondary DMR; Snrpn | null | null | null | null | null |
31,623,684 | Management of comminuted patellar fracture fixation using modified cerclage wiring. | Journal of orthopaedic surgery and research | J Orthop Surg Res | 14 | 1 | 10.1186/s13018-019-1385-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Although there are several different kinds of fixation techniques for displaced comminuted patellar fracture, the treatment remains a challenge for orthopaedic surgeons. The purpose of this study is to evaluate the effectiveness and safety of a fixation technique for comminuted patellar fracture fixation u... | Cerclage wiring; Comminuted fracture; Patellar fracture | 0.699 | 75 | Orthopedics and Sports Medicine; Surgery | Medicine | 2,019 |
31,623,683 | Tumour heterogeneity revealed by unsupervised decomposition of dynamic contrast-enhanced magnetic resonance imaging is associated with underlying gene expression patterns and poor survival in breast cancer patients. | Breast cancer research : BCR | Breast Cancer Res | 21 | 1 | 10.1186/s13058-019-1199-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Heterogeneity is a common finding within tumours. We evaluated the imaging features of tumours based on the decomposition of tumoural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data to identify their prognostic value for breast cancer survival and to explore their biological importance.... | Breast cancer; Convex analysis of mixtures; Dynamic magnetic resonance imaging; Gene pathway analysis; Recurrence-free survival | 2.407 | 182 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,682 | Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses. | Genome biology | Genome Biol | 20 | 1 | 10.1186/s13059-019-1830-0 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Single-cell RNA sequencing (scRNA-seq) is a powerful tool for studying complex biological systems, such as tumor heterogeneity and tissue microenvironments. However, the sources of technical and biological variation in primary solid tumor tissues and patient-derived mouse xenografts for scRNA-seq are not w... | Breast cancer; Gene expression; Ovarian cancer; Quality control; RNA-seq; Single cell; Tissue dissociation; Tumor microenvironment | null | null | null | null | null |
31,623,681 | HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes. | BMC pharmacology & toxicology | BMC Pharmacol Toxicol | 20 | 1 | 10.1186/s40360-019-0340-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD). As Angiotensin II (Ang II) is a critical active effector in the renin-angiotensin system (RAS) and was proved to be clo... | Angiotensin II; Inflammatory cytokine; Podocyte | null | null | null | null | null |
31,623,680 | A novel wearable device to deliver unconstrained, unpredictable slip perturbations during gait. | Journal of neuroengineering and rehabilitation | J Neuroeng Rehabil | 16 | 1 | 10.1186/s12984-019-0602-0 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Task-specific perturbation training is a widely studied means of fall prevention, utilizing techniques that induce slips or slip-like perturbations during gait. Though effective, these methods only simulate narrow ranges within the larger space of possible slipping conditions encountered in daily life. Her... | Balance; Falls; Gait; Perturbations; Slips; Task-specific Training; Wearable Technology | 1.139 | 129 | Health Informatics; Rehabilitation | Medicine | 2,019 |
31,623,679 | The complete mitochondrial genome and description of a new cryptic species of Benedenia Diesing, 1858 (Monogenea: Capsalidae), a major pathogen infecting the yellowtail kingfish Seriola lalandi Valenciennes in the South-East Pacific. | Parasites & vectors | Parasit Vectors | 12 | 1 | 10.1186/s13071-019-3711-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The monogenean Benedenia seriolae parasitizes fishes belonging to the genus Seriola, represents a species complex, and causes substantial impact on fish welfare in aquaculture systems worldwide. This study reports, for the first time, the complete mitochondrial genome of B. humboldti n. sp., a new cryptic ... | Disease; Flatworm; Fluke; Marine; Purifying selection; Vector | null | null | null | null | null |
31,623,677 | An efficient protocol to generate placental chorionic plate-derived mesenchymal stem cells with superior proliferative and immunomodulatory properties. | Stem cell research & therapy | Stem Cell Res Ther | 10 | 1 | 10.1186/s13287-019-1405-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Placenta-derived MSCs (P-MSCs) represent a promising tool for cell-based therapeutic applications. However, the increasing demand for P-MSCs in clinical trials makes high quality and large number of P-MSCs mandatory. Here, we aim to develop an efficient protocol for P-MSC isolation and culture. [METHODS] T... | Chorionic plate-derived MSCs; Isolation; Macrophage; Mesenchymal stem cells; The modified explant culture method | null | null | null | null | null |
31,623,676 | High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia. | Infectious diseases of poverty | Infect Dis Poverty | 8 | 1 | 10.1186/s40249-019-0600-2 | eng | 2,019 | 10 | 18 | 2,019 | 10 | 18 | [BACKGROUND] Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity, respectively. There has been no information on the status of co-infections of tuberculosis and parasitosis in Oromia Zone of Amhara Region and South Wollo, Ethiopia. Hence, this s... | Co-infection; Northeastern Ethiopia; Parasitosis; Tuberculosis; Undernutrition | 1.435 | 67 | Infectious Diseases; Medicine; Public Health, Environmental and Occupational Health | Medicine | 2,019 |
31,623,672 | Osteogenic potential of induced pluripotent stem cells from human adipose-derived stem cells. | Stem cell research & therapy | Stem Cell Res Ther | 10 | 1 | 10.1186/s13287-019-1402-y | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Bone regeneration is a crucial and challenging issue in clinical practice. Bone tissue engineering (BTE) with an optimal cell source may provide an ideal strategy for the reconstruction of bone defects. This study examined whether induced pluripotent stem cells (iPSCs) derived from adipose-derived stem cel... | Adipose-derived stem cells; Bone tissue engineering; Cryogel; Induced pluripotent stem cells; Osteogenic differentiation | null | null | null | null | null |
31,623,671 | Molecular mutations as a possible factor for determining extent of thyroid surgery. | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale | J Otolaryngol Head Neck Surg | 48 | 1 | 10.1186/s40463-019-0372-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Molecular testing of thyroid nodules is a diagnostic tool used to better understand the nature of thyroid nodules. The aim of this study is to better comprehend the relationship between specific mutations and aggressive behavior of the tumour as demonstrated on postoperative pathological analysis. [METHODS... | BRAF V600E; Extent of surgery; Molecular testing; RAS; TERT; Thyroid cancer | null | null | null | null | null |
31,623,670 | Modifying ankle foot orthosis stiffness in patients with calf muscle weakness: gait responses on group and individual level. | Journal of neuroengineering and rehabilitation | J Neuroeng Rehabil | 16 | 1 | 10.1186/s12984-019-0600-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] To improve gait, persons with calf muscle weakness can be provided with a dorsal leaf spring ankle foot orthosis (DLS-AFO). These AFOs can store energy during stance and return this energy during push-off, which, in turn, reduces walking energy cost. Simulations indicate that the effect of the DLS-AFO on w... | Ankle foot orthosis; Gait; Muscle weakness; Neuromuscular disease; Rehabilitation; Stiffness; Walking energy cost | 1.139 | 129 | Health Informatics; Rehabilitation | Medicine | 2,019 |
31,623,669 | Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process. | Stem cell research & therapy | Stem Cell Res Ther | 10 | 1 | 10.1186/s13287-019-1415-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] A refractory wound is a typical complication of diabetes and is a common outcome after surgery. Current approaches have difficulty in improving wound healing. Recently, non-expanded stromal vascular fraction (SVF), which is derived from mature fat, has opened up new directions for the treatment of refracto... | Human adipose-derived stem cells; Stromal vascular fraction; Wound healing | null | null | null | null | null |
31,623,668 | Levothyroxine-induced liver injury followed by complete recovery upon cessation of the drug: a case report. | Journal of medical case reports | J Med Case Rep | 13 | 1 | 10.1186/s13256-019-2244-z | eng | 2,019 | 10 | 18 | 2,019 | 10 | 18 | [BACKGROUND] Levothyroxine is a synthetic thyroxine and is the treatment of choice for hypothyroidism. It is a prohormone with minimal intrinsic activity. The drug is de-iodinated in peripheral tissue to form triiodothyronine, which is the active thyroid hormone. On initiation of treatment, levothyroxine is titrated, a... | Case report; Hepatitis; Hypothyroidism; Levothyroxine; Triiodothyronine | 0.255 | 43 | Medicine | Medicine | 2,019 |
31,623,666 | Risk factors for Blastocystis infection in HIV/AIDS patients with highly active antiretroviral therapy in Southwest China. | Infectious diseases of poverty | Infect Dis Poverty | 8 | 1 | 10.1186/s40249-019-0596-7 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Blastocystis is a widespread zoonotic protozoan of mammalian species, especially in HIV/AIDS individuals. The aim of this study was to analyze the prevalence and risk factors related with Blastocystis infection among HIV/AIDS patients in Southwest China. [METHODS] The cross-sectional study was performed in... | Blastocystis; Co-infection; HIV/AIDS; Interaction; Risk factor | 1.435 | 67 | Infectious Diseases; Medicine; Public Health, Environmental and Occupational Health | Medicine | 2,019 |
31,623,664 | Multimorbidity and healthcare resource utilization in Switzerland: a multicentre cohort study. | BMC health services research | BMC Health Serv Res | 19 | 1 | 10.1186/s12913-019-4575-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Multimorbidity is associated with higher healthcare resource utilization, but we lack data on the association of specific combinations of comorbidities with healthcare resource utilization. We aimed to identify the combinations of comorbidities associated with high healthcare resource utilization among mul... | Chronic diseases; Combinations; Comorbidity; Healthcare utilization; Length of stay; Multimorbidity; Potentially avoidable readmission; Readmission | 0.995 | 157 | Health Policy | Medicine | 2,019 |
31,623,662 | Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers. | Journal for immunotherapy of cancer | J Immunother Cancer | 7 | 1 | 10.1186/s40425-019-0737-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Immune checkpoint inhibitors (ICIs) have achieved impressive success in different cancer types, yet responses vary and predictive biomarkers are urgently needed. Growing evidence points to a link between DNA methylation and anti-tumor immunity, while clinical data on the association of genomic alterations ... | Biomarker; DNA methylation; Immune checkpoint blockade; Pan-cancer; TET1 | 4.194 | 136 | Cancer Research; Immunology; Immunology and Allergy; Molecular Medicine; Oncology; Pharmacology | Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,019 |
31,623,661 | Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands. | Stem cell research & therapy | Stem Cell Res Ther | 10 | 1 | 10.1186/s13287-019-1414-7 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] There are currently no effective treatments available for patients with irreversible loss of salivary gland (SG) function caused by radiation therapy for head and neck cancer. In this study, we have developed an effective culture method to enhance the anti-inflammatory and vasculogenic phenotypes of periph... | Anti-inflammation; Cell-based therapy; Macrophage; Peripheral blood mononuclear cells; Radiogenic salivary gland dysfunction; Vasculogenesis | null | null | null | null | null |
31,623,660 | Physiotherapy students' DiSC behaviour styles can be used to predict the likelihood of success in clinical placements. | BMC medical education | BMC Med Educ | 19 | 1 | 10.1186/s12909-019-1825-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Behaviour can be defined as the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal and/or external stimuli, excluding responses more easily understood as developmental changes. Unlike personality traits, that are thought to be biologically ... | Assessment; Behaviour; Clinical education; DiSC styles; Physiotherapy | 0.831 | 107 | Education; Medicine | Medicine; Social Sciences | 2,019 |
31,623,659 | Caffeine and sodium bicarbonate supplementation alone or together improve karate performance. | Journal of the International Society of Sports Nutrition | J Int Soc Sports Nutr | 16 | 1 | 10.1186/s12970-019-0313-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The ergogenic properties of acute caffeine (CAF) and sodium bicarbonate (NaHCO3) ingestion on athletic performance have been previously investigated. However, each sport has unique physiological and technical characteristics which warrants optimizing supplementations strategies for maximizing performance. ... | Blood lactate; Caffeine; Ergogenic aid; Karate; Karate-specific aerobic test; Rate of perceived exertion; Sodium bicarbonate; Time to exhaustion | 1.274 | 74 | Food Science; Nutrition and Dietetics; Sports Science | Agricultural and Biological Sciences; Health Professions; Nursing | 2,019 |
31,623,658 | Early prognostication of neurological outcome by heart rate variability in adult patients with out-of-hospital sudden cardiac arrest. | Critical care (London, England) | Crit Care | 23 | 1 | 10.1186/s13054-019-2603-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Most deaths of comatose survivors of out-of-hospital sudden cardiac arrest result from withdrawal of life-sustaining treatment (WLST) decisions based on poor neurological prognostication and the family's intention. Thus, accurate prognostication is crucial to avoid premature WLST decisions. However, target... | Glasgow outcome scale; Heart rate variability; Out-of-hospital sudden cardiac arrest; Prognostication; Targeted temperature management | 2.384 | 229 | Critical Care and Intensive Care Medicine | Medicine | 2,019 |
31,623,657 | Predicting acute coronary syndrome in males and females with chest pain who call an emergency medical communication centre. | Scandinavian journal of trauma, resuscitation and emergency medicine | Scand J Trauma Resusc Emerg Med | 27 | 1 | 10.1186/s13049-019-0670-y | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Chest pain is a frequent reason for calls in emergency medical communication centre (EMCC). Detecting a coronary origin by phone is a challenge. This is especially so as the presentations differ according to gender. We aimed to establish and validate a sex-based model to predict a coronary origin of chest ... | Accuracy; Acute coronary syndrome; Chest pain; Emergency medical communication Centre; Sex disparity | 1.107 | 73 | Critical Care and Intensive Care Medicine; Emergency Medicine | Medicine | 2,019 |
31,623,655 | Ethnobotanical research in Cava de' Tirreni area, Southern Italy. | Journal of ethnobiology and ethnomedicine | J Ethnobiol Ethnomed | 15 | 1 | 10.1186/s13002-019-0330-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] To best of our knowledge, this is the first quantitative ethnobotanical study with the aim of documenting the local knowledge and practices of using plants for curing diseases in the Cava de' Tirreni area, Salerno Province, Campania Region, Italy. The present ethnobotanical field study, carried out during ... | Ethnobotany; Ethnopharmacology; Traditional medicine; Traditional uses | 0.775 | 99 | Agricultural and Biological Sciences; Complementary and Alternative Medicine; Cultural Studies; Health | Agricultural and Biological Sciences; Medicine; Social Sciences | 2,019 |
31,623,653 | circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. | Journal of hematology & oncology | J Hematol Oncol | 12 | 1 | 10.1186/s13045-019-0800-z | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences. Recent studies have reported that cancer-associated chromosomal translocations could juxtapose distant complementary repetitive intronic sequences, resulting in ... | Circular RNA; Leukemia progression; MLL-AF4 fusion protein | null | null | null | null | null |
31,623,652 | Quantitative nuclear histomorphometric features are predictive of Oncotype DX risk categories in ductal carcinoma in situ: preliminary findings. | Breast cancer research : BCR | Breast Cancer Res | 21 | 1 | 10.1186/s13058-019-1200-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Oncotype DX (ODx) is a 12-gene assay assessing the recurrence risk (high, intermediate, and low) of ductal carcinoma in situ (pre-invasive breast cancer), which guides clinicians regarding prescription of radiotherapy. However, ODx is expensive, time-consuming, and tissue-destructive. In addition, the actu... | Ductal carcinoma in situ; Nucleus; Oncotype DX; Quantitative histomorphometry | 2.407 | 182 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,651 | MEIS2C and MEIS2D promote tumor progression via Wnt/β-catenin and hippo/YAP signaling in hepatocellular carcinoma. | Journal of experimental & clinical cancer research : CR | J Exp Clin Cancer Res | 38 | 1 | 10.1186/s13046-019-1417-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] MEIS2 has been identified as one of the key transcription factors in the gene regulatory network in the development and pathogenesis of human cancers. Our study aims to identify the regulatory mechanisms of MEIS2 in hepatocellular carcinoma (HCC), which could be targeted to develop new therapeutic strategi... | Alternative splicing; CDC-73; HCC; Hippo; MEIS2; Wnt | null | null | null | null | null |
31,623,650 | Mangiferin alleviates experimental peri-implantitis via suppressing interleukin-6 production and Toll-like receptor 2 signaling pathway. | Journal of orthopaedic surgery and research | J Orthop Surg Res | 14 | 1 | 10.1186/s13018-019-1387-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] TLR2 (Toll-like receptor 2) signaling and its downstream proinflammatory cytokines are considered to be important in the progression of peri-implantitis. A natural medicine, mangiferin has exhibited modulatory effect on TLR2 signaling and anti-inflammatory effects on different diseases. The objective of th... | Bone loss; Interleukin-6; Mangiferin; Peri-implantitis; Toll-like receptor 2 | 0.699 | 75 | Orthopedics and Sports Medicine; Surgery | Medicine | 2,019 |
31,623,649 | Metastatic behavior and overall survival according to breast cancer subtypes in stage IV inflammatory breast cancer. | Breast cancer research : BCR | Breast Cancer Res | 21 | 1 | 10.1186/s13058-019-1201-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Distant metastatic disease is frequently observed in inflammatory breast cancer (IBC), with a poor prognosis as a consequence. The aim of this study was to analyze the association of hormone receptor (HR) and human epidermal growth factor receptor-2 (HER2) based breast cancer subtypes in stage IV inflammat... | Breast cancer subtype; Inflammatory breast cancer; Metastases; Survival | 2.407 | 182 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,648 | Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. | Molecular neurodegeneration | Mol Neurodegener | 14 | 1 | 10.1186/s13024-019-0337-1 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and transgenic mice have demonstr... | Albumin; Amyloid; Apolipoprotein E; Cre-loxP; Mouse model; apoE; apoE particle | 4.04 | 126 | Cellular and Molecular Neuroscience; Molecular Biology; Neurology | Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience | 2,019 |
31,623,647 | pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles. | Journal of nanobiotechnology | J Nanobiotechnology | 17 | 1 | 10.1186/s12951-019-0543-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pathogen Listeria monocytogenes has developed a strategy to secrete Listerio... | Drug delivery; Listeriolysin O toxin; Lysosomal escape; Nanoparticles; Quantum dots | 1.335 | 125 | Applied Microbiology and Biotechnology; Bioengineering; Biomedical Engineering; Medicine; Pharmaceutical Science; Molecular Medicine; Nanoscience and Nanotechnology | Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Engineering; Immunology and Microbiology; Materials Science; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,019 |
31,623,646 | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark. | Breast cancer research : BCR | Breast Cancer Res | 21 | 1 | 10.1186/s13058-019-1203-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Screening mammography works better in fatty than in dense breast tissue. Computerized assessment of parenchymal texture is a non-subjective method to obtain a refined description of breast tissue, potentially valuable in addition to breast density scoring for the identification of women in need of suppleme... | BI-RADS; Mammographic density; Mammography; Parenchymal texture marker; Sensitivity | 2.407 | 182 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,645 | Prevalence and risk factors of HIV infection among people who inject drugs in Cambodia: findings from a national survey. | Substance abuse treatment, prevention, and policy | Subst Abuse Treat Prev Policy | 14 | 1 | 10.1186/s13011-019-0232-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Globally, people who inject drugs (PWID) continue to be among the most vulnerable populations to acquire infection of human immunodeficiency virus (HIV). The most recent national survey found that nearly a quarter of PWID in Cambodia were infected with HIV in 2012. The aim of this study is to estimate the ... | Cambodia; HIV risk; Harm reduction; Injecting drug use; National survey; Prevalence | null | null | null | null | null |
31,623,641 | Correlation of tilt of the anterior pelvic plane angle with anatomical pelvic tilt and morphological configuration of the acetabulum in patients with developmental dysplasia of the hip: a cross-sectional study. | Journal of orthopaedic surgery and research | J Orthop Surg Res | 14 | 1 | 10.1186/s13018-019-1382-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] It was previously reported that pelvises with developmental dysplasia of the hip are tilted anteriorly, which increases bony coverage of the femoral head. This study aimed to investigate the correlation between anatomical parameters of the pelvis such as pelvic incidence and anatomical pelvic tilt and func... | Cross-sectional study; Developmental dysplasia of the hip; Hip; Pelvic tilt | 0.699 | 75 | Orthopedics and Sports Medicine; Surgery | Medicine | 2,019 |
31,623,637 | The 'connectaholic' behind the curtain: medical student use of computer devices in the clinical setting and the influence of patients. | BMC medical education | BMC Med Educ | 19 | 1 | 10.1186/s12909-019-1811-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The use of mobile devices such as tablets and laptops by students to support their learning is now ubiquitous. The clinical setting is an environment, which lends itself to the use of mobile devices as students are exposed to novel clinical scenarios that may require rapid location of information to addres... | Clinical placement; Medical education; Medical students; Portable devices; Technology enhanced learning | 0.831 | 107 | Education; Medicine | Medicine; Social Sciences | 2,019 |
31,623,636 | The influence of dental experience on a dental implant navigation system. | BMC oral health | BMC Oral Health | 19 | 1 | 10.1186/s12903-019-0914-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] This study evaluated the operating performance of an implant navigation system used by dental students and dentists of prosthodontic background with varying levels of experience. A surgical navigation system and optical tracking system were used, and dentists' accuracies were evaluated in terms of differen... | Accuracy; Dental implant; Navigation system; Surgical experience | 0.731 | 80 | Dentistry | Dentistry | 2,019 |
31,623,635 | Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review. | BMC cancer | BMC Cancer | 19 | 1 | 10.1186/s12885-019-6224-x | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Lymphoma and dysplasia are rare complications of long-standing Crohn's disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a Crohn's disease patient. [CASE PRESENTATION] A 50-year-old male patient presented with right lower... | Adenoma; Lymphomatous polyposis; MALT | 1.186 | 171 | Cancer Research; Genetics; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,634 | A Delphi consensus study for teaching "Basic Trauma Management" to third-year medical students. | Scandinavian journal of trauma, resuscitation and emergency medicine | Scand J Trauma Resusc Emerg Med | 27 | 1 | 10.1186/s13049-019-0675-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The Basic-Trauma Management (BTM) course has been taught to third-year medical students in small groups for many years without substantial changes. With the introduction of a new curriculum for Swiss medical students, it was necessary to revise the BTM content and re-align it. Our aim was to identify core ... | Curriculum; Delphi; Skills; Teaching; Trauma; Undergraduate | 1.107 | 73 | Critical Care and Intensive Care Medicine; Emergency Medicine | Medicine | 2,019 |
31,623,633 | Antibiotic prescriptions in Italian hospitalised children after serial point prevalence surveys (or pointless prevalence surveys): has anything actually changed over the years? | Italian journal of pediatrics | Ital J Pediatr | 45 | 1 | 10.1186/s13052-019-0722-y | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Point prevalence surveys have been used in several studies to provide immediate and easily comparable information about antibiotic use and showed that about one third of hospitalised children had on ongoing antimicrobial prescription during their hospital admission. The aim of this study, as part of the Gl... | Antimicrobial stewardship; Antimicrobials; Children; Point prevalence surveys | 0.525 | 65 | Pediatrics, Perinatology and Child Health | Medicine | 2,019 |
31,623,632 | Fit for fight - self-reported health in military women: a cross-sectional study. | BMC women's health | BMC Womens Health | 19 | 1 | 10.1186/s12905-019-0820-4 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Substantial research has found that women assess their health as poor relative to men, but the reasons for this are not fully understood. Military women are characterised by good health and the ability to work in an archetypically male culture. Thus, studies on the gender pattern of self-reported health in... | Female; Military; Norway; Self-reported health; Surveys | 0.777 | 73 | Medicine; Obstetrics and Gynecology; Reproductive Medicine | Medicine | 2,019 |
31,623,631 | Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study. | BMC pregnancy and childbirth | BMC Pregnancy Childbirth | 19 | 1 | 10.1186/s12884-019-2499-9 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, based on refractoriness to initial first-line treatment, was proposed as an alternative to comm... | Definition; Maternal morbidity; Maternal mortality; Postpartum haemorrhage | 1.275 | 122 | Obstetrics and Gynecology | Medicine | 2,019 |
31,623,628 | Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression. | Molecular cancer | Mol Cancer | 18 | 1 | 10.1186/s12943-019-1078-z | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Circular RNAs (circRNAs) have recently been identified as potential functional modulators of the cellular physiology processes. The study aims to uncover the potential clinical value and driving molecular mechanisms of circRNAs in gallbladder cancer (GBC). [PATIENTS AND METHODS] We performed RNA sequencing... | Gallbladder cancer; PKLR; PTBP1; circFOXP1; miR-370 | 4.581 | 222 | Cancer Research; Molecular Medicine; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,627 | Effects of insect diets on the gastrointestinal tract health and growth performance of Siberian sturgeon (Acipenser baerii Brandt, 1869). | BMC veterinary research | BMC Vet Res | 15 | 1 | 10.1186/s12917-019-2070-y | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Insects in the fish diet are a natural source of protein, fat, and other nutrients. These meals are considered an ecological replacement for fishmeal to improve growth parameters. The application of insect meals to fish diets has been studied, especially in continental fish. Data regarding the effects of i... | Fish nutrition; Hermetia illucens; Insect meals; Microbiology; Siberian sturgeon; Tenebrio molitor | 0.787 | 86 | Veterinary; Medicine | Medicine; Veterinary | 2,019 |
31,623,626 | DNA methylation exploration for ARDS: a multi-omics and multi-microarray interrelated analysis. | Journal of translational medicine | J Transl Med | 17 | 1 | 10.1186/s12967-019-2090-1 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development and progression of many diseases, would be used as potential therapeutic targets to improve the trea... | ARDS; DNA methylation; Interrelated analysis; Multi-omics; mRNA | 1.474 | 153 | Biochemistry, Genetics and Molecular Biology; Medicine | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,620 | Psychological primitives can make sense of biopsychosocial factor complexity in psychopathology. | BMC medicine | BMC Med | 17 | 1 | 10.1186/s12916-019-1435-1 | eng | 2,019 | 10 | 18 | 2,019 | 10 | 18 | [BACKGROUND] Many agree that the biopsychosocial contributions to psychopathology are complex, yet it is unclear how we can make sense of this complexity. One approach is to reduce this complexity to a few necessary and sufficient biopsychosocial factors; although this approach is easy to understand, it has little expl... | Complexity; Indeterminacy; Psychological primitives; Psychopathology; Suicide | 3.552 | 199 | Medicine | Medicine | 2,019 |
31,623,619 | Feminisation of the health workforce and wage conditions of health professions: an exploratory analysis. | Human resources for health | Hum Resour Health | 17 | 1 | 10.1186/s12960-019-0406-0 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The feminisation of the global health workforce presents a unique challenge for human resource policy and health sector reform which requires an explicit gender focus. Relatively little is known about changes in the gender composition of the health workforce and its impact on drivers of global health workf... | Feminist economics; Gender; Health workforce; Inequalities; Wage conditions; Wage gap | 1.208 | 89 | Public Administration; Public Health, Environmental and Occupational Health | Medicine; Social Sciences | 2,019 |
31,623,616 | Utilizing a user-centered approach to develop and assess pharmacogenomic clinical decision support for thiopurine methyltransferase. | BMC medical informatics and decision making | BMC Med Inform Decis Mak | 19 | 1 | 10.1186/s12911-019-0919-4 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] A pharmacogenomic clinical decision support tool (PGx-CDS) for thiopurine medications can help physicians incorporate pharmacogenomic results into prescribing decisions by providing up-to-date, real-time decision support. However, the PGx-CDS user interface may introduce errors and promote alert fatigue. T... | Clinical decision support; Formative evaluation; Pharmacogenomics; TPMT; User-centered approach | 0.908 | 107 | Health Informatics; Health Policy | Medicine | 2,019 |
31,623,613 | Economic barriers, evidentiary gaps, and ethical conundrums: a qualitative study of physicians' challenges recommending HPV vaccination to older gay, bisexual, and other men who have sex with men. | International journal for equity in health | Int J Equity Health | 18 | 1 | 10.1186/s12939-019-1067-2 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The human papillomavirus (HPV) is the most common sexually transmitted infection (STI) worldwide. Gay, bisexual, and other men who have sex with men (GBM), and GBM living with HIV in particular, are disproportionately impacted by HPV-associated cancers. The HPV vaccine, given early enough in life, may mark... | HIV; HPV vaccination; Human papillomavirus (HPV); Physician practices; Qualitative | 1.393 | 93 | Health Policy; Public Health, Environmental and Occupational Health | Medicine | 2,019 |
31,623,612 | "As we have gathered with a common problem, so we seek a solution": exploring the dynamics of a community dialogue process to encourage community participation in family planning/contraceptive programmes. | BMC health services research | BMC Health Serv Res | 19 | 1 | 10.1186/s12913-019-4490-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Community dialogues have been widely used as a method for community engagement and participation to cover a broad range of areas. However, there has been limited documentation and evaluation of the process, particularly as a method towards achieving family planning and contraception (FP/C) programme goals.... | Community participation; Contraception; Family planning; Health provider; Unmet need | 0.995 | 157 | Health Policy | Medicine | 2,019 |
31,623,611 | Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers. | Environmental health : a global access science source | Environ Health | 18 | 1 | 10.1186/s12940-019-0525-z | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Nitrate is converted to nitrite in the human body and subsequently can react with amines and amides in the gastrointestinal tract to form N-nitroso compounds (NOCs), which are known to be carcinogenic in animals. Humans can be exposed to nitrate via consumption of drinking water and diet, especially green ... | Drinking water; Endogenous nitrosation; Genotoxicity; Human dietary intervention study; N-nitroso compounds; Nitrate; Nitrite; Processed red and unprocessed white meat; Vitamin C | 1.424 | 126 | Health, Toxicology and Mutagenesis; Medicine; Public Health, Environmental and Occupational Health | Environmental Science; Medicine | 2,019 |
31,623,610 | Dynamic response of microglia/macrophage polarization following demyelination in mice. | Journal of neuroinflammation | J Neuroinflammation | 16 | 1 | 10.1186/s12974-019-1586-1 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The glial response in multiple sclerosis (MS), especially for recruitment and differentiation of oligodendrocyte progenitor cells (OPCs), predicts the success of remyelination of MS plaques and return of function. As a central player in neuroinflammation, activation and polarization of microglia/macrophage... | Diffusion tensor imaging; Focal demyelination model; Microglia/macrophage; Multiple sclerosis; Neuroinflammation; Oligodendrocyte/oligodendrocyte progenitor cells; Sensorimotor function | 2.187 | 168 | Cellular and Molecular Neuroscience; Immunology; Neurology; Neuroscience | Immunology and Microbiology; Neuroscience | 2,019 |
31,623,609 | Barriers and facilitators to development and implementation of a rural primary health care intervention for dementia: a process evaluation. | BMC health services research | BMC Health Serv Res | 19 | 1 | 10.1186/s12913-019-4548-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] With rural population aging there are growing numbers of people with dementia in rural and remote settings. The role of primary health care (PHC) is critical in rural locations, yet there is a lack of rural-specific PHC models for dementia, and little is known about factors influencing the development, imp... | null | 0.995 | 157 | Health Policy | Medicine | 2,019 |
31,623,606 | CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. | Molecular cancer | Mol Cancer | 18 | 1 | 10.1186/s12943-019-1080-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Emerging evidence has shown that circular RNAs (circRNAs) play essential roles in cancer biology and are potential biomarkers and targets for cancer therapy. However, the expression and function of circRNAs in ovarian carcinogenesis and its progression remain elusive. [METHODS] RNA sequencing was performed... | AKT1; BRCA1; CircPLEKHM3; DNAJB6; KLF4; Ovarian cancer; Prognosis; miR-9 | 4.581 | 222 | Cancer Research; Molecular Medicine; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,605 | Detection of large rearrangements in a hereditary pan-cancer panel using next-generation sequencing. | BMC medical genomics | BMC Med Genomics | 12 | 1 | 10.1186/s12920-019-0587-3 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Healthcare providers increasingly use information about pathogenic variants in cancer predisposition genes, including sequence variants and large rearrangements (LRs), in medical management decisions. While sequence variant detection is typically robust, LRs can be difficult to detect and characterize and ... | Confirmatory testing; Deletion; Duplication; Hereditary pan-cancer panel testing; Large rearrangements; MLPA; Microarray-CGH; Next-generation sequencing | 1.078 | 99 | Genetics; Genetics | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,604 | Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies. | BMC pediatrics | BMC Pediatr | 19 | 1 | 10.1186/s12887-019-1700-7 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] In Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care. The purpose of the study was to compare the outcome of two cohorts of NICU-admitted very preterm infants born bet... | Bronchopulmonary dysplasia; Cohort studies; Intraventricular haemorrhage; Morbidity; Mortality; Necrotising enterocolitis; Periventricular leukomalacia; Preterm; Retinopathy of prematurity; Very low birth weight | 0.853 | 106 | Pediatrics, Perinatology and Child Health | Medicine | 2,019 |
31,623,603 | Association between benign thyroid disease and breast cancer: a single center experience. | BMC endocrine disorders | BMC Endocr Disord | 19 | 1 | 10.1186/s12902-019-0426-8 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The relationship between breast cancer (BC) and thyroid disease (TD) is still controversial. The aim of the study was to investigate the possible coexistence of TD in patients with newly diagnosed BC and its correlation with BC clinical presentation with regard to menopausal status and stage of disease. [M... | Benign thyroid disease; Breast cancer; Menopause; Thyroid disorders | 0.853 | 63 | Endocrinology, Diabetes and Metabolism; Medicine | Medicine | 2,019 |
31,623,602 | Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait. | BMC cancer | BMC Cancer | 19 | 1 | 10.1186/s12885-019-6155-6 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. Limited data regarding clinicopathological profile and management exists. [METHODS] We retrospectively reviewed the MD Anderson Canc... | CUP; Immunohistochemistry; Molecular; Neoplasms; Pathology; Prognosis; Sarcomatoid carcinoma; Unknown primary | 1.186 | 171 | Cancer Research; Genetics; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,019 |
31,623,601 | Prevalence of chronic obstructive pulmonary disease (COPD) and its associated factors among adults in Abeshge District, Ethiopia: a cross sectional study. | BMC pulmonary medicine | BMC Pulm Med | 19 | 1 | 10.1186/s12890-019-0946-z | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Chronic obstructive pulmonary disease (COPD) is one of the major public health problems worldwide. Despite an increasing burden of COPD in the world, it is often a neglected disease in low income countries and COPD prevalence studies are rare in Sub-Saharan Africa. The objective of this study was to determ... | COPD; Ethiopia; Prevalence; Risk factors | 1.095 | 85 | Pulmonary and Respiratory Medicine | Medicine | 2,019 |
31,623,600 | Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression. | BMC psychiatry | BMC Psychiatry | 19 | 1 | 10.1186/s12888-019-2302-5 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] The potential link between sleep disorders and suicidal behaviour has been the subject of several reviews. We performed this meta-analysis to estimate the overall association between sleep disorders and suicidal behaviour and to identify a more specific relationship in patients with depression. [METHODS] A... | Depression; Meta-analysis; Sleep disorder; Suicidal behaviour; Systematic review | 1.341 | 151 | Psychiatry and Mental Health | Medicine | 2,019 |
31,623,599 | Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8[+] T lymphocyte exhaustion. | BMC biotechnology | BMC Biotechnol | 19 | 1 | 10.1186/s12896-019-0559-x | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cells. In activated lymphocytes, LAG3 expression is involved in negative control of cell activation/p... | CD8+ T lymphocytes; LAG3; Lymphocyte exhaustion; Phage display; Reconstituted scFv; Single-chain variable fragment | 0.962 | 99 | Biotechnology | Biochemistry, Genetics and Molecular Biology | 2,019 |
31,623,597 | Cost-effectiveness of a mindfulness-based mental health promotion program: economic evaluation of a nonrandomized controlled trial with propensity score matching. | BMC public health | BMC Public Health | 19 | 1 | 10.1186/s12889-019-7585-4 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Mental health promotion programs have been shown to reduce the burden associated with mental distress and prevent the onset of mental disorders, but evidence of cost-effectiveness is scarce. [OBJECTIVE] To evaluate the cost-effectiveness of a mindfulness-based mental health prevention program provided by h... | Cost-effectiveness; Health promotion; Implementation research; Mental health; Prevention | 1.198 | 211 | Public Health, Environmental and Occupational Health | Medicine | 2,019 |
31,623,596 | How clinical teaching teams deal with educational change: 'we just do it'. | BMC medical education | BMC Med Educ | 19 | 1 | 10.1186/s12909-019-1815-4 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] In postgraduate medical education, program directors are in the lead of educational change within clinical teaching teams. As change is part of a social process, it is important to not only focus on the program director but take their other team members into account. The purpose of this study is to provide... | Change management; Clinical teaching teams; Curriculum change; Postgraduate medical education | 0.831 | 107 | Education; Medicine | Medicine; Social Sciences | 2,019 |
31,623,595 | Pathological upgrading in prostate cancer treated with surgery in the United Kingdom: trends and risk factors from the British Association of Urological Surgeons Radical Prostatectomy Registry. | BMC urology | BMC Urol | 19 | 1 | 10.1186/s12894-019-0526-9 | eng | 2,019 | 10 | 17 | 2,019 | 10 | 17 | [BACKGROUND] Accurate grading at the time of diagnosis if fundamental to risk stratification and treatment decision making in patients with prostate cancer. Whilst previous studies have demonstrated significant pathological upgrading and downgrading following radical prostatectomy (RP), these were based on historical c... | Gleason grade; Needle biopsy; Pathological; Prostate cancer; Radical prostatectomy | 0.693 | 57 | Medicine; Reproductive Medicine; Urology | Medicine | 2,019 |
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